diff --git a/lib/database_cleaner/active_record.rb b/lib/database_cleaner/active_record.rb
index b3b6055..5fee357 100644
--- a/lib/database_cleaner/active_record.rb
+++ b/lib/database_cleaner/active_record.rb
@@ -4,6 +4,7 @@
 ActiveSupport.on_load(:active_record) do
   require 'database_cleaner/active_record/base'
   require 'database_cleaner/active_record/transaction'
+  require 'database_cleaner/active_record/serializable_transaction'
   require 'database_cleaner/active_record/truncation'
   require 'database_cleaner/active_record/deletion'
 
diff --git a/lib/database_cleaner/active_record/serializable_transaction.rb b/lib/database_cleaner/active_record/serializable_transaction.rb
new file mode 100644
index 0000000..f252768
--- /dev/null
+++ b/lib/database_cleaner/active_record/serializable_transaction.rb
@@ -0,0 +1,13 @@
+# See: https://github.com/DatabaseCleaner/database_cleaner/pull/681
+return if Gem::Version.new(DatabaseCleaner::VERSION) < Gem::Version.new("2.0.2")
+
+# See: https://github.com/rails/rails/pull/55542
+return if ActiveRecord.gem_version < Gem::Version.new("8.1.0")
+
+module DatabaseCleaner
+  module ActiveRecord
+    class SerializableTransaction < Transaction
+      TRANSACTION_PARAMETERS = { isolation: :serializable }.freeze
+    end
+  end
+end
diff --git a/lib/database_cleaner/active_record/transaction.rb b/lib/database_cleaner/active_record/transaction.rb
index c7391f0..dec7177 100644
--- a/lib/database_cleaner/active_record/transaction.rb
+++ b/lib/database_cleaner/active_record/transaction.rb
@@ -1,6 +1,8 @@
 module DatabaseCleaner
   module ActiveRecord
     class Transaction < Base
+      TRANSACTION_PARAMETERS = {}.freeze
+
       def start
         connection = if ::ActiveRecord.version >= Gem::Version.new("7.2")
           connection_class.lease_connection
@@ -9,7 +11,7 @@ def start
         end
 
         # Hack to make sure that the connection is properly set up before cleaning
-        connection.transaction {}
+        connection.transaction(**transaction_parameters) { nil }
 
         connection.begin_transaction joinable: false
       end
@@ -25,6 +27,12 @@ def clean
 
         connection_class.connection_pool.release_connection
       end
+
+      private
+
+      def transaction_parameters
+        self.class.const_get(:TRANSACTION_PARAMETERS)
+      end
     end
   end
 end
diff --git a/spec/database_cleaner/active_record/serializable_transaction_spec.rb b/spec/database_cleaner/active_record/serializable_transaction_spec.rb
new file mode 100644
index 0000000..c091a15
--- /dev/null
+++ b/spec/database_cleaner/active_record/serializable_transaction_spec.rb
@@ -0,0 +1,109 @@
+require 'support/database_helper'
+require 'database_cleaner/active_record/serializable_transaction'
+
+return unless defined?(DatabaseCleaner::ActiveRecord::SerializableTransaction)
+
+RSpec.describe DatabaseCleaner::ActiveRecord::SerializableTransaction do
+  subject(:strategy) { described_class.new }
+
+  DatabaseHelper.with_all_dbs do |helper|
+    next if helper.db == :sqlite3
+
+    context "using a #{helper.db} connection" do
+      around do |example|
+        helper.setup
+        example.run
+        helper.teardown
+      end
+
+      describe "#clean" do
+        context "after an initial #start" do
+          before do
+            strategy.start
+
+            ActiveRecord::Base.transaction(isolation: :serializable) do
+              2.times { User.create! }
+              2.times { Agent.create! }
+            end
+          end
+
+          it "should clean all tables" do
+            expect { strategy.clean }
+              .to change { [User.count, Agent.count] }
+              .from([2,2])
+              .to([0,0])
+          end
+        end
+
+        context "with fixtures before an initial #start" do
+          before do
+            2.times { User.create! }
+            strategy.start
+            ActiveRecord::Base.transaction(isolation: :serializable) do
+              2.times { Agent.create! }
+            end
+          end
+
+          it "should not clean fixtures" do
+            expect { strategy.clean }
+              .to change { [User.count, Agent.count] }
+              .from([2,2])
+              .to([2,0])
+          end
+        end
+
+        context "without an initial start" do
+          before do
+            ActiveRecord::Base.transaction(isolation: :serializable) do
+              2.times { User.create! }
+              2.times { Agent.create! }
+            end
+          end
+
+          it "does nothing" do
+            expect { strategy.clean }
+              .to_not change { [User.count, Agent.count] }
+          end
+        end
+      end
+
+      describe "#cleaning" do
+        context "with records" do
+          it "should clean all tables" do
+            strategy.cleaning do
+              ActiveRecord::Base.transaction(isolation: :serializable) do
+                2.times { User.create! }
+                2.times { Agent.create! }
+              end
+              expect([User.count, Agent.count]).to eq [2,2]
+            end
+            expect([User.count, Agent.count]).to eq [0,0]
+          end
+        end
+
+        context "with fixtures" do
+          it "should not clean fixtures" do
+            2.times { User.create! }
+            strategy.cleaning do
+              ActiveRecord::Base.transaction(isolation: :serializable) do
+                2.times { Agent.create! }
+              end
+              expect([User.count, Agent.count]).to eq [2,2]
+            end
+            expect([User.count, Agent.count]).to eq [2,0]
+          end
+        end
+
+        context "without an initial start" do
+          it "does nothing" do
+            2.times { User.create! }
+            2.times { Agent.create! }
+            expect { strategy.cleaning {} }
+              .to_not change { [User.count, Agent.count] }
+              .from([2,2])
+          end
+        end
+      end
+    end
+  end
+end