diff --git a/cli/src/main/java/org/incenp/obofoundry/sssom/cli/SimpleCLI.java b/cli/src/main/java/org/incenp/obofoundry/sssom/cli/SimpleCLI.java
index b836e7d..0ec9902 100644
--- a/cli/src/main/java/org/incenp/obofoundry/sssom/cli/SimpleCLI.java
+++ b/cli/src/main/java/org/incenp/obofoundry/sssom/cli/SimpleCLI.java
@@ -71,6 +71,8 @@
 import org.semanticweb.owlapi.model.OWLOntology;
 import org.semanticweb.owlapi.model.OWLOntologyCreationException;
 import org.semanticweb.owlapi.model.OWLOntologyManager;
+import org.tukaani.xz.LZMA2Options;
+import org.tukaani.xz.XZOutputStream;
 
 import picocli.CommandLine.ArgGroup;
 import picocli.CommandLine.Command;
@@ -833,6 +835,10 @@ private OutputStream getOutputStream(String filename, CompressionFormat comp)
             out = new GZIPOutputStream(out);
             break;
 
+        case XZ:
+            out = new XZOutputStream(out, new LZMA2Options());
+            break;
+
         case NONE:
             break;
         }
diff --git a/ext/pom.xml b/ext/pom.xml
index 6aa1adf..6791b35 100644
--- a/ext/pom.xml
+++ b/ext/pom.xml
@@ -32,6 +32,11 @@
       <artifactId>owlapi-distribution</artifactId>
       <version>4.5.29</version>
     </dependency>
+    <dependency>
+      <groupId>org.tukaani</groupId>
+      <artifactId>xz</artifactId>
+      <version>1.12</version>
+    </dependency>
     <dependency>
       <groupId>io.github.liveontologies</groupId>
       <artifactId>elk-owlapi</artifactId>
diff --git a/ext/src/main/java/org/incenp/obofoundry/sssom/util/CompressionFormat.java b/ext/src/main/java/org/incenp/obofoundry/sssom/util/CompressionFormat.java
index 609e7ff..b442b8c 100644
--- a/ext/src/main/java/org/incenp/obofoundry/sssom/util/CompressionFormat.java
+++ b/ext/src/main/java/org/incenp/obofoundry/sssom/util/CompressionFormat.java
@@ -35,7 +35,14 @@ public enum CompressionFormat {
      * 
      * @see <a href="https://www.rfc-editor.org/info/rfc1952/">RFC 1952</a>
      */
-    GZIP(".gz");
+    GZIP(".gz"),
+
+    /**
+     * The XZ file format from the XZ Utils project.
+     * 
+     * @see <a href="https://tukaani.org/xz/xz-file-format.txt">XZ file format</a>
+     */
+    XZ(".xz");
 
     private String extension;
 
diff --git a/ext/src/main/java/org/incenp/obofoundry/sssom/util/ReaderFactory.java b/ext/src/main/java/org/incenp/obofoundry/sssom/util/ReaderFactory.java
index 408f452..88a4143 100644
--- a/ext/src/main/java/org/incenp/obofoundry/sssom/util/ReaderFactory.java
+++ b/ext/src/main/java/org/incenp/obofoundry/sssom/util/ReaderFactory.java
@@ -34,6 +34,7 @@
 import org.incenp.obofoundry.sssom.TSVReader;
 import org.incenp.obofoundry.sssom.TSVReader.SeparatorMode;
 import org.incenp.obofoundry.sssom.rdf.RDFReader;
+import org.tukaani.xz.XZInputStream;
 
 /**
  * A class providing helper methods to obtain SSSOM reader objects.
@@ -513,6 +514,10 @@ private InputStream getInputStream(String filename, boolean allowStdin, Compress
             in = new GZIPInputStream(in);
             break;
 
+        case XZ:
+            in = new XZInputStream(in);
+            break;
+
         case NONE:
             break;
         }