diff --git a/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.spec.tsx b/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.spec.tsx
index b9bc471acdc..e49dc563406 100644
--- a/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.spec.tsx
+++ b/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.spec.tsx
@@ -23,6 +23,24 @@ describe('InPlaceEditor', () => {
         fireEvent.blur(input);
         await screen.findByText('Jane Doe');
     });
+
+    it('should save when focus moves to an element outside the editor', async () => {
+        const { container } = render(<Basic delay={0} />);
+
+        const value = await screen.findByText('John Doe');
+        value.click();
+
+        const input = await screen.findByDisplayValue('John Doe');
+        fireEvent.change(input, { target: { value: 'Jane Doe' } });
+
+        const outsideButton = document.createElement('button');
+        outsideButton.textContent = 'Next';
+        container.appendChild(outsideButton);
+
+        fireEvent.blur(input, { relatedTarget: outsideButton });
+
+        await screen.findByText('Jane Doe');
+    });
     it('should revert to the previous version on error', async () => {
         jest.spyOn(console, 'error').mockImplementation(() => {});
         render(<Basic delay={0} updateFails />);
diff --git a/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.tsx b/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.tsx
index d8756b61b12..6ebbf056fdd 100644
--- a/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.tsx
+++ b/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.tsx
@@ -197,16 +197,27 @@ export const InPlaceEditor = <
 
     const handleBlur = (event: React.FocusEvent) => {
         if (event.relatedTarget) {
-            return;
+            // Focus moved to an element inside the editor — ignore
+            if (event.currentTarget.contains(event.relatedTarget as Node)) {
+                return;
+            }
+            // Focus moved to a MUI portal (e.g. Select dropdown) — ignore
+            if (
+                (event.relatedTarget as HTMLElement).closest?.(
+                    '.MuiPopover-root, .MuiModal-root, .MuiMenu-root'
+                )
+            ) {
+                return;
+            }
         }
+
         if (cancelOnBlur) {
             dispatch({ type: 'cancel' });
             return;
         }
+
         if (state.state === 'editing') {
-            // trigger the parent form submit
-            // to save the changes
-            (submitButtonRef.current as HTMLButtonElement).click();
+            (submitButtonRef.current as HTMLButtonElement)?.click();
         }
     };