diff --git a/Lib/concurrent/interpreters/_queues.py b/Lib/concurrent/interpreters/_queues.py
index 5f3ee0934de59d..fc4ee595f3aa99 100644
--- a/Lib/concurrent/interpreters/_queues.py
+++ b/Lib/concurrent/interpreters/_queues.py
@@ -220,12 +220,12 @@ def put(self, obj, block=True, timeout=None, *,
             timeout = int(timeout)
             if timeout < 0:
                 raise ValueError(f'timeout value must be non-negative')
-            end = time.time() + timeout
+            end = time.monotonic() + timeout
         while True:
             try:
                 _queues.put(self._id, obj, unboundop)
             except QueueFull:
-                if timeout is not None and time.time() >= end:
+                if timeout is not None and time.monotonic() >= end:
                     raise  # re-raise
                 time.sleep(_delay)
             else:
@@ -255,12 +255,12 @@ def get(self, block=True, timeout=None, *,
             timeout = int(timeout)
             if timeout < 0:
                 raise ValueError(f'timeout value must be non-negative')
-            end = time.time() + timeout
+            end = time.monotonic() + timeout
         while True:
             try:
                 obj, unboundop = _queues.get(self._id)
             except QueueEmpty:
-                if timeout is not None and time.time() >= end:
+                if timeout is not None and time.monotonic() >= end:
                     raise  # re-raise
                 time.sleep(_delay)
             else:
diff --git a/Lib/test/test_interpreters/test_queues.py b/Lib/test/test_interpreters/test_queues.py
index 77334aea3836b9..baa772b3b36795 100644
--- a/Lib/test/test_interpreters/test_queues.py
+++ b/Lib/test/test_interpreters/test_queues.py
@@ -2,7 +2,9 @@
 import pickle
 import threading
 from textwrap import dedent
+import time
 import unittest
+from unittest import mock
 
 from test.support import import_helper, Py_DEBUG
 # Raise SkipTest if subinterpreters not supported.
@@ -354,6 +356,19 @@ def test_get_timeout(self):
         with self.assertRaises(queues.QueueEmpty):
             queue.get(HUGE_TIMEOUT, 0.1)
 
+    def test_timeout_uses_monotonic_clock(self):
+        # gh-153005: the deadline must be computed from the monotonic clock,
+        # since the wall clock can be adjusted while the call is blocked.
+        queue = queues.create(1)
+        with mock.patch.object(queues, 'time', wraps=time) as fake_time:
+            with self.assertRaises(queues.QueueEmpty):
+                queue.get(timeout=0)
+            queue.put(None)
+            with self.assertRaises(queues.QueueFull):
+                queue.put(None, timeout=0)
+        fake_time.monotonic.assert_called()
+        fake_time.time.assert_not_called()
+
     def test_get_nowait(self):
         queue = queues.create()
         with self.assertRaises(queues.QueueEmpty):
diff --git a/Misc/NEWS.d/next/Library/2026-07-19-17-45-00.gh-issue-153005.F6WH92.rst b/Misc/NEWS.d/next/Library/2026-07-19-17-45-00.gh-issue-153005.F6WH92.rst
new file mode 100644
index 00000000000000..7f3d10b3072ef9
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2026-07-19-17-45-00.gh-issue-153005.F6WH92.rst
@@ -0,0 +1,4 @@
+:meth:`!concurrent.interpreters.Queue.get` and
+:meth:`!concurrent.interpreters.Queue.put` now compute their ``timeout``
+deadline from :func:`time.monotonic` instead of the wall clock, so adjusting
+the system clock during the call no longer makes them over- or under-wait.