diff --git a/packages/void/src/plugin-node-target.ts b/packages/void/src/plugin-node-target.ts
index eefdcf6ac..61687174b 100644
--- a/packages/void/src/plugin-node-target.ts
+++ b/packages/void/src/plugin-node-target.ts
@@ -81,6 +81,9 @@ function honoMiddleware(
       response.headers.forEach((value: string, key: string) => {
         res.setHeader(key, value);
       });
+      // Headers yields each Set-Cookie separately and setHeader keeps only the
+      // last one, so send them all together.
+      res.setHeader('set-cookie', response.headers.getSetCookie());
 
       if (response.body) {
         const reader = response.body.getReader();
diff --git a/packages/void/test/unit/plugin-node-target.test.ts b/packages/void/test/unit/plugin-node-target.test.ts
new file mode 100644
index 000000000..b0e50f266
--- /dev/null
+++ b/packages/void/test/unit/plugin-node-target.test.ts
@@ -0,0 +1,101 @@
+import { mkdirSync, mkdtempSync, rmSync, writeFileSync } from 'node:fs';
+import { createServer, type IncomingMessage, type ServerResponse } from 'node:http';
+import type { AddressInfo } from 'node:net';
+import { tmpdir } from 'node:os';
+import { join } from 'node:path';
+import type { Plugin, PreviewServer, ViteDevServer } from 'vite';
+import { afterEach, describe, expect, it, vi } from 'vite-plus/test';
+import { nodeTargetPlugin } from '../../src/plugin-node-target.ts';
+import { getHookHandler } from '../helpers/vite-hooks.ts';
+
+type Middleware = (req: IncomingMessage, res: ServerResponse, next: () => void) => void;
+
+const tempDirs: Array<string> = [];
+
+afterEach(() => {
+  vi.restoreAllMocks();
+  for (const dir of tempDirs.splice(0)) {
+    rmSync(dir, { recursive: true, force: true });
+  }
+});
+
+function servePlugin(): Plugin {
+  const plugin = nodeTargetPlugin('node').find((p) => p.configureServer);
+  if (!plugin) {
+    throw new Error('Expected the node target serve plugin.');
+  }
+  return plugin;
+}
+
+async function requestThrough(middleware: Middleware, path: string): Promise<Response> {
+  const server = createServer((req, res) => {
+    middleware(req, res, () => {
+      res.statusCode = 404;
+      res.end();
+    });
+  });
+  await new Promise<void>((resolve) => server.listen(0, '127.0.0.1', resolve));
+  try {
+    const { port } = server.address() as AddressInfo;
+    const response = await fetch(`http://127.0.0.1:${port}${path}`);
+    await response.text();
+    return response;
+  } finally {
+    await new Promise<void>((resolve) => server.close(() => resolve()));
+  }
+}
+
+describe('nodeTargetPlugin request bridge', () => {
+  it('keeps every Set-Cookie header in dev', async () => {
+    let middleware: Middleware | undefined;
+    const app = {
+      fetch: async () => {
+        const headers = new Headers({ 'content-type': 'text/plain' });
+        headers.append('set-cookie', 'session=abc; Path=/');
+        headers.append('set-cookie', 'csrf=xyz; Path=/');
+        return new Response('ok', { headers });
+      },
+    };
+    const server = {
+      middlewares: { use: (fn: Middleware) => (middleware = fn) },
+      ssrLoadModule: async () => ({ default: app }),
+    } as unknown as ViteDevServer;
+    getHookHandler(servePlugin().configureServer)!.call({} as never, server);
+
+    const response = await requestThrough(middleware!, '/login');
+
+    expect(response.status).toBe(200);
+    expect(response.headers.get('content-type')).toBe('text/plain');
+    expect(response.headers.getSetCookie()).toEqual(['session=abc; Path=/', 'csrf=xyz; Path=/']);
+  });
+
+  it('keeps every Set-Cookie header in preview', async () => {
+    const root = mkdtempSync(join(tmpdir(), 'void-node-target-'));
+    tempDirs.push(root);
+    mkdirSync(join(root, 'dist', 'ssr'), { recursive: true });
+    writeFileSync(
+      join(root, 'dist', 'ssr', 'app.js'),
+      `export default {
+  fetch: async () => {
+    const headers = new Headers();
+    headers.append('set-cookie', 'session=abc; Path=/');
+    headers.append('set-cookie', 'csrf=xyz; Path=/');
+    return new Response('ok', { headers });
+  },
+};
+`,
+    );
+    vi.spyOn(process, 'cwd').mockReturnValue(root);
+
+    let middleware: Middleware | undefined;
+    const server = {
+      middlewares: { use: (fn: Middleware) => (middleware = fn) },
+    } as unknown as PreviewServer;
+    getHookHandler(servePlugin().configurePreviewServer)!.call({} as never, server);
+
+    const response = await requestThrough(middleware!, '/login');
+
+    expect(response.status).toBe(200);
+    expect(response.headers.getSetCookie()).toEqual(['session=abc; Path=/', 'csrf=xyz; Path=/']);
+  });
+});