@holoscript/alphafold-plugin

Protein structure prediction for HoloScript — part of the HoloScript ecosystem.

Brings protein structure prediction into HoloScript scenes. Supports the AlphaFold API (cloud) and local ColabFold (GPU). The plugin targets the AlphaFold API; ColabFold compatibility covers local runs.

Features

• Cloud protein structure prediction via the AlphaFold API
• Local prediction via ColabFold on your own GPU
• pLDDT confidence coloring in VR
• Multimer prediction for protein complexes
• PAE (Predicted Aligned Error) heatmap visualization
• Batch prediction for comparing variants

Installation

npm install holoscript @holoscript/alphafold-plugin
pip install requests

Usage

object "My Protein" @alphafold_predict @structure_confidence {
  sequence: "MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGAEKAVQVKVK",
  mode: "api",
  color_by: "confidence",
}

See examples/protein-prediction.holo for more.

Requirements

• Node.js 18+
• Python 3.10+
• AlphaFold API key (for cloud mode) or ColabFold (for local mode)

Status

Experimental. Core prediction and visualization traits are implemented; expect API and interface changes.

License

MIT © HoloScript Contributors