Add pylimma to ecosystem packages - #388
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Summary
This PR proposes adding
pylimmato the scverse ecosystem packages list.Proposed metadata file:
packages/pylimma/meta.yamlChecklist for adding packages
Mandatory
Name of the tool:
pylimmaShort description:
pylimmais a Anndata-native Python port of R limma, validated against the existing R package on real biological datasets. It has particular application to mass-spectrometry proteomics differential abundance analysis (as demonstrated in one of the package tutorials), alongside its traditional microarray, bulk RNA-seq, and pseudobulk single-cell use cases.How does the package use scverse data structures (please describe in a few sentences):
Any function that consumes expression data (
voom,lm_fit,normalize_between_arrays,array_weights,duplicate_correlation, etc.) accepts anAnnDataobject in place of a flat matrix. Outputs are written toadata.layers[...], fits are stored inadata.uns[...], and results are retrieved fromAnnDatavia the usualtop_table/decide_testscalls. This means that a pylimma workflow slots directly into an existing AnnData pipeline without any conversion step.Beyond unit tests, correctness against the R reference is validated across ~230 function-level comparisons and using real biological datasets spanning microarray, RNAseq, proteomics, single-cell, and splicing workflows, with worst-case relative differences documented per function. Full methodology and results of the validation are available in the preprint
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